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Journal: Pharmaceutics
Article Title: A Distribution-Based Metric for Quantifying Dispersibility in Dry Powder Inhalers
doi: 10.3390/pharmaceutics18030283
Figure Lengend Snippet: Baseline particle size, solid-state structure, and morphology of spray-dried formulations. ( A ) Cumulative volume particle size distributions (Q 3 ) obtained by laser diffraction under RODOS dispersion at 3.0 bar, defining the maximally dispersed reference state for each formulation. Spray-dried inulin and trehalose exhibit similar fully dispersed size profiles, whereas mannitol displays a broader distribution shifted toward larger particle sizes. ( B ) Powder X-ray diffraction (pXRD) patterns of spray-dried trehalose, inulin, and mannitol. Trehalose and inulin show amorphous halo patterns, while mannitol exhibits distinct Bragg reflections consistent with a crystalline structure. ( C ) Scanning electron microscopy (SEM) images of spray-dried particles following dispersion, acquired at identical magnification (2000×) to enable qualitative comparison of primary particle morphology; higher magnification imaging of mannitol was limited by charging artifacts. Trehalose and inulin particles are predominantly spherical, with trehalose appearing smoother and inulin exhibiting greater surface corrugation, whereas mannitol particles display angular, faceted morphologies characteristic of crystalline materials. Scale bars = 5 µm.
Article Snippet: Particle morphology of the spray-dried powders in their maximally dispersed state was examined using
Techniques: Dispersion, Formulation, Electron Microscopy, Comparison, Imaging